Potts and guy equation skin permeability
WebAlgorithm derived by Potts & Guy* from extensive database of ~100 K p values across human skin in vitro following their application in water: logk p 2.7 0. 71 logP 0. 0061 MW P … Web1 Mar 2006 · A mathematical model is developed that can predict skin permeability to small (MW < 500 Da), hydrophobic solutes based on the fundamental transport properties of …
Potts and guy equation skin permeability
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WebAbstract. Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to … Web23 Aug 2007 · The mathematical model of Potts and Guy was derived by analysing the data of Flynn 8 and the best-fitted empirical equation is given in the following form (3) where …
WebWe investigated the sources of data used in recently published predictive models of skin permeability. It was found that skin permeability coefficients for 63 compounds are … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Web15 Apr 2024 · The skin permeability (Kp) defines the rate of a chemical penetrating across the stratum corneum. This value is widely used to quantitatively describe the transport of … Web1 Nov 1995 · A facile interpretation of a considerable body of skin permeability measurements is presented that very adequately describes the dependence of Kp upon …
WebIn the assessment of the uptake of a chemical after dermal exposure, for instance, the dermal permeability of the skin is often estimated using the Potts-Guy quantitative …
WebThe skin permeation coefficient (k p) is a measure of the conductance of skin to a particular chemical from a particular vehicle. This calculator estimates the value of k p from an … moers superflyWebExperimentally derived permeability coefficients (K-P) were also compared to that derived from two skin permeation models namely Potts & Guy and Robinson (revised) models in … moers theeWebDeterministic and probabilistic approaches are used here to calculate the human health risk associated with trihalomethanes (THMs) in the water supply of three communities … moers theaterWeb10 May 2024 · An exposure route exposure routeThe way a chemical pollutant enters an organism after contact, e.g., by ingestion, inhalation, or dermal absorption. is the way that … moers thoraxchirurgieWebThe Potts and Guy (1992) equation is summarised in equation 1 for the calculation of the permeation coefficient across the epidermal membrane: K p ... Estimating skin … moerth regauWeb28 Feb 2024 · Chromatographic retention data collected on immobilized keratin (KER) or immobilized artificial membrane (IAM) stationary phases were used to predict skin permeability coefficient (log Kp) and bioconcentration factor (log BCF) of structurally unrelated compounds. Models of both properties contained, apart from chromatographic … moertl wilkins campbellWebOverall fit of the developed model(s) to the permeability data is somewhat better than for the Potts–Guy equation and variants thereof; however, marked improvement is seen in … moerth florian