Laminin g like domain

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August undefined, 2024

TīmeklisThe sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding … Comparison of Charge Distribution in Calcium Bound G Domains(A) The G5 … Introduction. Muscular dystrophies are a clinically, genetically, and biochemically … Exostosin-like glycosyltransferase 2: EXTL2: EXTL2: 1p21: NM_001439 … In brief, several core M3 structures have been proposed to be attached to the … Because dystroglycan binds laminin, and dystrophin binds actin, the complex … The cytidyltransferase domain adopts the characteristic Rossmann-like α/β fold … The transcript is predicted to encode a 3165-aa extracellular protein containing …

RCSB PDB - 1H30: C-terminal LG domain pair of human Gas6

TīmeklisPikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the EGFLAM gene.. Pikachurin is a dystroglycan-interacting protein which has an essential role in the precise interactions between the photoreceptor ribbon … TīmeklisLaminin G domain-like (LG) modules of approximately 180-200 residues are found in a number of extracellular and receptor proteins and often are present in tandem arrays. … hendy lease

Laminin G-like domains: dystroglycan-specific lectins - PubMed

Tīmeklis2000. gada 1. aug. · Abstract. Laminin G domain-like (LG) modules of approximately 180–200 residues are found in a number of extracellular and receptor proteins and … Tīmeklis2002. gada 21. aug. · Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment … TīmeklisThe EGF-like domain is an evolutionary conserved protein domain, ... The EGF-like domain is also part of laminins, an important group of extracellular proteins. The EGF-like domains are usually masked in intact membranes, but become exposed when the membrane is destroyed, e.g. during inflammation, thereby stimulating membrane … laptop text blurry

Phenotype of CNTNAP1: a study of patients demonstrating a

Tīmeklis2000. gada 15. febr. · In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal structure of the N-terminal G domain of SHBG in complex with 5alpha-dihydrotestosterone at 1.55 A resolution reveals both the architecture of the steroid-binding site and the quaternary … TīmeklisEGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also … laptop that flips aroundTīmeklis2002. gada 28. nov. · Domain: 58-277: Laminin G-like: BLAST Add. ... PTHR15261:SF4 THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN 1 hit; PROSITE. View protein in PROSITE; PS50912 EAR 7 hits; Pfam. View protein in Pfam; PF03736 EPTP 5 hits; SMART. View protein … hendy leigh road

"Tīmeklis2009. gada 15. dec. · Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. " - Laminin g like domain

Laminin g like domain

Tīmeklis2024. gada 11. apr. · Mature Laminin α4 is a subunit of Laminin 411, Laminin 421, and Laminin 423. Mature Laminin α4 is a 1792 amino acid (aa) residue protein that has a Laminin N-terminal domain, four Laminin EGF-like domains, the coiled-coil domain, and five C-terminal tandem Laminin G-like domains. The G-like domains contain … Tīmeklislaminin G-like domain. Discover > laminin G-like domain. 3DPX-014448 Crystal structure of the heterotrimeric... sacomuelas. EXTRACELLULAR MATRIX, CELL …

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TīmeklisAbstract. A unique O-mannose-linked glycan on the transmembrane protein dystroglycan binds a number of extracellular matrix proteins containing laminin G … Tīmeklis2024. gada 21. marts · LAMA5 (Laminin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include Bent Bone Dysplasia Syndrome 2 and Nephrotic Syndrome, Type 26.Among its related pathways are Integrin Pathway and ERK Signaling.Gene Ontology (GO) annotations related to this gene include …

TīmeklisModeling the fifth laminin-epidermal growth factor like domain A homology model of the fifth EGF Lam domain was created using the YASARA & WHAT IF Twinset homology modeling module 42,43 . Tīmeklis2024. gada 28. apr. · We used a set of chimeric proteins in which each of the C-terminal laminin G-like (LG) domains of ProS1 were swapped with those of Gas6, as well as a set of ProS1 mutants with novel added glycosylations within LG1. Alongside wildtype ProS1, only the chimera containing ProS1 LG1 domain stimulated Tyro3 and Erk …

Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. They also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein complex and Lutheran blood group glycoprotein. Through these interactions, laminins critically contribute to cell attachment and differentiation, cell shape and movement, maintenance of tissue phenotype, and promotion of ti… http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00282

Tīmeklis2024. gada 6. dec. · Search life-sciences literature (Over 39 million articles, preprints and more)

TīmeklisPikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is … hendy lennox v grahame puttick 1984TīmeklisSHBG has two laminin G-like domains which form pockets that bind hydrophobic molecules. The steroids are bound by the LG domain at the amino end of the protein. Inside the pocket of the domain is a serine residue that attracts the two different types of steroids at different points, thus changing their orientation. Androgens bind at the C3 ... hendy lennox exeterTīmeklisThe Laminin G or LNS domain (for Laminin-alpha, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [ ( PUBMED:1975589) ( PUBMED:9480764) ]. The laminin globular (G) domain can be found in one to several copies in various laminin family … hendy lennox caseTīmeklis2000. gada 1. febr. · The C-terminus of the laminin alpha chain contains a tandem of five laminin G-like (LG) domains. We report the 2.0 A crystal structure of the laminin alpha2 LG4-LG5 domain pair, which harbours binding sites for heparin and the cell surface receptor alpha-dystroglycan, and is 41% identical to the laminin alpha1 E3 … laptop that runs sims 4Tīmeklis2000. gada 3. apr. · The α chains are unique in that they contain at their C-termini a tandem of five laminin G-like (LG) domains, LG1–LG5. The C-terminal LG4–LG5 … hendy lennox v grahame puttickTīmeklis2024. gada 6. marts · b–d Modelling of the Laminin G-like 1 domain only (residues 174–355), based on template 3poyA, for wild-type CASPR and variants p.Cys323Arg and p.Leu212Pro respectively; protein is shown in ... hendy lotusTīmeklis1999. gada 28. sept. · In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal structure of the N-terminal G domain of SHBG in complex with 5alpha-dihydrotestosterone at 1.55 A resolution reveals both the architecture of the steroid-binding site and the quaternary … laptop thin\u0026light dell inspiron 15 3515