Formin-binding protein
WebJan 8, 2024 · Formin-binding protein 1/17 (FNBP1/FBP17), as a membrane-bound protein, is wildly expressed in eukaryotic cells and performs a critical role in tumor tumorigenesis and progression. However, the relationship between FNBP1 and immune infiltrating cells, prognostic value in patients still require comprehensive understanding. … WebJul 14, 2024 · Formin binding protein 17 (FBP17) belongs to Cdc-42 interacting protein 4 subfamily of F-BAR proteins. Recently, we had reported that FBP17 was overexpressed in invasive breast cancer cells...
Formin-binding protein
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WebFormin proteins are potent regulators of actin dynamics. Most eukaryotes have multiple formin isoforms, suggesting diverse cellular roles. Formins are modular proteins, … WebJul 3, 2001 · The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL -fusion partner in acute myelogeneous leukemia Uta Fuchs, Gönna …
WebJul 3, 2001 · Herein, we report the fusion of a gene that encodes the human formin-binding protein 17 ( FBP17) to MLL at 11q23 in a 14-month-old child with AML. After the identification of a chimeric MLL fusion gene, we tested its transforming ability with the help of retroviral gene transfer. WebMar 29, 2024 · 29-Mar-2024 Summary This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration.
WebApr 24, 2024 · Eukaryotic cells contain a large number of actin binding proteins of different functions, locations and concentrations. ... WebFormin proteins were recognized as effectors of Rho GTPases some 15 years ago. They contribute to different cellular actin cytoskeleton structures by their ability to polymerize straight actin filaments at the barbed end. While not all formins necessarily interact with Rho GTPases, a subgroup of mammalian formins, termed Diaphanous-related ...
WebMay 24, 2024 · The first ‘formin’ was so named to reflect the defect in mouse limb formation that resulted from mutations in the limb deformity locus. In fact, the limb deformity phenotype is now attributed to two neighboring genes: Fmn1, of the FMN-subtype of formins, and gremlin, an unrelated gene. Shortly after Fmn1 was identified, a similar gene, …
WebJan 25, 2024 · Formins are actin-binding proteins that are key to maintaining the actin cytoskeleton in cells. However, molecular mechanisms controlling the stability of formin proteins in plants remain unknown. steve wright barry from watfordWebFeb 5, 2024 · This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. steve wright ccrcWebMay 25, 2024 · Li et al., Rice actin-binding protein RMD is a key link in the auxin-actin regulatory loop that controls cell growth. Proc Natl Acad Sci U S A 111, 10377-10382 (2014). 7. Z. Zhang et al., RICE MORPHOLOGY DETERMINANT encodes the type II formin FH5 and regulates rice morphogenesis. Plant Cell 23, 681-700 (2011). steve wright and daughter loft conversionsWebAug 1, 2009 · Formin-binding proteins are modulators of formins [8] which are involved in actin polymerization, especially at the fast-growing end [9,10]. Among 32 mammalian formin-binding proteins [11],... steve wright annual salaryWebMar 24, 2003 · Whereas other WW domains have been shown to fold with single-exponential kinetics, the WW domain from murine formin-binding protein 28 has recently been shown to fold with biphasic kinetics. By using a combination of kinetics and thermodynamics to characterize a simple model for this protein, the origins of the … steve wright cyndi robinsonWebJul 14, 2024 · Formin binding protein 17 (FBP17) belongs to Cdc-42 interacting protein 4 subfamily of F-BAR proteins. Recently, we had reported that FBP17 was overexpressed … steve wright david wilson homesWebOct 20, 2015 · FORMIN-BINDING PROTEIN 4; FNBP4 Alternative titles; symbols FBP30 KIAA1014 HGNC Approved Gene Symbol: FNBP4 Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,716,494-47,767,341 (from NCBI) TEXT Description FNBP4 belongs to a class of WW domain proteins that bind to proline- and arginine-rich motifs ( … steve wright dj ill