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WebJun 20, 2013 · PreviewIns and Outs of Kinase DFG Motifs. Ins and Outs of Kinase DFG Motifs. In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known “gatekeeper” residue, regulate “in” versus “out” conformations of the conserved “DFG” motif. These findings suggest yet ... http://univ.ency-education.com/uploads/1/3/1/0/13102001/physio2an_05_physiologie_renale_diapos-guedjati.pdf WebWhat does DFG out mean? The DFG phenylalanine packs into a hydrophobic pocket between one residue from the N-lobe and one residue from the C-lobe, thus creating a hydrophobic regulatory spine. This packing interaction is referred to as the “DFG-in” conformation. …. These are referred to as “DFG-out” conformations. thin converging lens equation