Cisplatin kidney injury

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August undefined, 2024

WebMar 27, 2024 · Cisplatin causes tubular damage and acute kidney injury (AKI) [ 10, 11 ]. Although AKI is a long-term risk factor for chronic kidney disease and death [ 12, 13 ], no clinical studies have examined the association between cisplatin-induced AKI (c-AKI) and postoperative complications. WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ...

PSTPIP2 inhibits cisplatin-induced acute kidney injury by ... - Nature

WebPatients who receive a single dose of cisplatin may suffer from reversible kidney injury, while large doses or multiple courses of treatment may cause irreversible renal failure . WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 citi online bank reviews

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WebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ... WebFeb 18, 2024 · Decades of research have resulted in significant insight into the pathogenesis of cisplatin-induced AKI, including tubular cell injury and death, vascular damage, oxidative stress, and an... WebDec 12, 2024 · PSTPIP2 administration suppressed kidney injury in response to cisplatin treatment, suggesting that PSTPIP2 can be a part of a useful therapeutic strategy for treatment of cisplatin nephrotoxicity ... citi online business

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Caught in the crossfire: cancer, cisplatin therapy, and kidney injury ...

WebSep 1, 2024 · Iron might play a critical role in mediating cisplatin-induced kidney injury; however, the association between CIN and ferroptosis remains unclear. In this study, we found that cisplatin induced an increase in renal iron content and that this effect could be prevented by a ferroptosis inhibitor. 2. Materials and methods WebMar 20, 2024 · Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment. Methods This was a … dibbs - sports cardsWebJan 3, 2024 · Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower survival and increased economic burden, there is no pharmacological agent to effectively treat CI-AKI. The disease is hallmarked by acute tubular necrosis of the proximal tubular … dibby dibby diamonds elybeatmaker

"WebApr 25, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. " - Cisplatin kidney injury

Cisplatin kidney injury

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular …

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WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed.

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute …

WebDec 21, 2024 · Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ]. WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as injury to the renal vasculature, results in vasoconstriction, reduced blood flow, and ischemic injury.

WebDec 16, 2024 · Cisplatin induces acute ischemic injury, resulting in decreased renal medullary blood flow ( 24) and renal tubular cell damage ( 25 ). Meanwhile, cisplatin can block calcium ion channels to reduce COX-2 and prostaglandin, cause vasoconstriction, and eventually lead to aggravation of hypoxia ( 26 ).

WebWhile the pathogenesis of cisplatin-induced kidney injury is complex, the major underlying mechanisms converge on oxidative stress, inflammation, and renal fibrosis [ 11, 17 ], which may involve major NAD + -dependent redox enzymes, such as mitochondrial complex I, CD38, NNT, NADK, PARP, alpha-keto acid dehydrogenases, and sirtuins. citi online checkingWebSep 1, 2004 · Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity. Clin Pharmacol Ther. 2024 04; 101 (4):510-518. PMID: 28002630. View in: PubMed George B, You D, Joy MS, Aleksunes LM. Xenobiotic transporters and kidney injury. Adv Drug Deliv Rev. 2024 07 … dibby dibby sound just danceWebIntroduction. Cisplatin is an extensively used chemotherapeutic drug for various types of human cancer. However, 20–35% of patients are diagnosed with renal dysfunction after cisplatin intervention, even after hydration pretreatment. 1 Acute kidney injury (AKI) is the primary manifestation of cisplatin-induced nephrotoxicity. The mechanisms include DNA … citi online credit card bankingWebApr 6, 2015 · Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. The initial injury triggers a proliferative response in renal tubular cells, which in the presence of cellular damage can further accelerate renal injury. dibby dibby soundWebNational Center for Biotechnology Information dibby houseWebMay 8, 2024 · Key Points español 中文 (chinese) . Question What are the characteristics and risk factors associated with acute kidney injury among children receiving cisplatin infusions?. Findings In this cohort study of … dibby dibby sound (extended)WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. In this study, IS reduced the expression of Mas receptor ... dibbs training video